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CDKN2A as transcriptomic marker for muscle-invasive bladder cancer risk stratification and therapy decision-making

Worst, Thomas S. ; Weis, Cleo-Aron ; Stöhr, Robert ; Bertz, Simone ; Eckstein, Markus ; Otto, Wolfgang ; Breyer, Johannes ; Hartmann, Arndt ; Bolenz, Christian ; Wirtz, Ralph M. ; Erben, Philipp


Deletions of the cell cycle control gene CDKN2A are described as progression markers of non-muscle invasive bladder cancer and to be associated with fibroblast growth factor 3 (FGFR3) mutations. The prognostic role of CDKN2A RNA expression in muscle invasive bladder cancer (MIBC) is under discussion. In 80 MIBC patients (m/f60/20) who underwent radical cystectomy the expression of CDKN2A and ...


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