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Quantitative lipidomic analysis of mouse lung during postnatal development by electrospray ionization tandem mass spectrometry

Ehrhardt, Harald ; Karnati, Srikanth ; Garikapati, Vannuruswamy ; Liebisch, Gerhard ; Van Veldhoven, Paul P. ; Spengler, Bernhard ; Schmitz, Gerd ; Baumgart-Vogt, Eveline


Lipids play very important roles in lung biology, mainly reducing the alveolar surface tension at the air-liquid interface thereby preventing end-expiratory collapse of the alveoli. In the present study we performed an extensive quantitative lipidomic analysis of mouse lung to provide the i) total lipid quantity, ii) distribution pattern of the major lipid classes, iii) composition of individual ...


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