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Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae

Iacovella, Maria G. ; Bremang, Michael ; Basha, Omer ; Giacò, Luciano ; Carotenuto, Walter ; Golfieri, Cristina ; Szakal, Barnabas ; Dal Maschio, Marianna ; Infantino, Valentina ; Beznoussenko, Galina V. ; Joseph, Chinnu R. ; Visintin, Clara ; Mironov, Alexander A. ; Visintin, Rosella ; Branzei, Dana ; Ferreira-Cerca, Sébastien ; Yeger-Lotem, Esti ; De Wulf, Peter



Abstract

The Saccharomyces cerevisiae kinase/adenosine triphosphatase Rio1 regulates rDNA transcription and segregation, pre-rRNA processing and small ribosomal subunit maturation. Other roles are unknown. When overexpressed, human ortholog RIOK1 drives tumor growth and metastasis. Likewise, RIOK1 promotes 40S ribosomal subunit biogenesis and has not been characterized globally. We show that Rio1 manages ...

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