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Differences in Duloxetine Dosing Strategies in Smoking and Nonsmoking Patients

Augustin, Marc ; Schoretsanitis, Georgios ; Hiemke, Christoph ; Gründer, Gerhard ; Haen, Ekkehard ; Paulzen, Michael


Background: For certain psychotropic drugs, such as clozapine or olanzapine, the influence of smoking on drug metabolism is well studied. Tobacco smoke increases the metabolism of drugs that are substrates for cytochrome P450 (CYP) 1A2 due to CYP induction. The antidepressant duloxetine, acting as a serotonin-norepinephrine reuptake inhibitor, is mainly metabolized via CYP1A2. To date, little is ...


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