Dokumentenart: | Artikel | ||||
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Titel eines Journals oder einer Zeitschrift: | Clinical Neurology and Neurosurgery | ||||
Verlag: | ELSEVIER SCIENCE BV | ||||
Ort der Veröffentlichung: | AMSTERDAM | ||||
Band: | 172 | ||||
Seitenbereich: | S. 177-182 | ||||
Datum: | 2018 | ||||
Institutionen: | Medizin > Lehrstuhl für Neurochirurgie Medizin > Abteilung für Neuropathologie Medizin > Lehrstuhl für Strahlentherapie | ||||
Identifikationsnummer: |
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Stichwörter / Keywords: | LOW-GRADE GLIOMAS; GUIDED SURGERY; RESECTION; PERFORMANCE; MICROSCOPE; F-18-FET; Low grade glioma; Fluorescence-guided surgery; Fluorescein sodium; FET-PET; FDG-PET-CT; Pilocytic astrocytoma; Oligodendroglioma; Anaplastic astrocytoma; YELLOW 560 nm filter | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 46801 |
Zusammenfassung
Objectives: We report on five patients with gadolinium-negative (non-enhancing magnetic resonance imaging-MRI) but F-18-fluoroethyl tyrosine positron-emission tomography (FET-PET) positive glioma (NEG) undergoing surgery under fluorescence-guidance with fluorescein sodium 10% (FL, Alkon, Germany) in combination with a dedicated light filter (YELLOW 560 nm, Carl Zeiss Meditec, Germany). Patients ...
Zusammenfassung
Objectives: We report on five patients with gadolinium-negative (non-enhancing magnetic resonance imaging-MRI) but F-18-fluoroethyl tyrosine positron-emission tomography (FET-PET) positive glioma (NEG) undergoing surgery under fluorescence-guidance with fluorescein sodium 10% (FL, Alkon, Germany) in combination with a dedicated light filter (YELLOW 560 nm, Carl Zeiss Meditec, Germany). Patients and method: Since 2017, five patients (3 female, 2 male; mean age 45.4 years) underwent fluorescence guided surgery for supratentorial, intracerebral lesions which showed no contrast-enhancement in the preoperative MRI but were, however, strongly suspicious for gliomas. Accordingly, all patients received a preoperative FET-PET scan and detailed histopathological workup was performed. After giving written informed consent, all patients received 5 mg/kg of FL at the induction of anesthesia. Surgery was conducted under white light and under the YELLOW 560 nm filter. We reviewed the surgical protocols, navigational storage and the image databases of our surgical microscopes for evidence of intraoperative fluorescence that corresponded to the FET-PET positive area. Results: In all patients we found distinct accordances between the FET-PET positive areas and the fluorescing regions within the targeted lesions. Histopathological workup of the fluorescent tissue revealed anaplastic oligodendroglioma, IDH-mutant and 1p/19-codeleted (WHO grade III) (n = 2), anaplastic astrocytoma, IDH-mutant (WHO grade III) (n = 1), oligodendroglioma, IDH-mutant and 1p/19q-codeleted (WHO grade II) (n = 1) and pilocytic astrocytoma (WHO grade I) (n = 1). No adverse events were noted. Discussion and conclusion: Despite the lack of gadolinium-enhancement in the preoperative MRI, all patients intravenously received FL to guide resection. Irrespective of the final grading, FL was extremely helpful in detecting the lesions and in identifying their border zones. In selected patients with NEG, but strong metabolic activity according to the FET-PET, FL may significantly increase the accuracy of surgery.
Metadaten zuletzt geändert: 28 Jul 2021 17:04