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RELN signaling modulates glioblastoma growth and substrate‐dependent migration

Schulze, Markus ; Violonchi, Christ ; Swoboda, Stefan ; Welz, Tobias ; Kerkhoff, Eugen ; Hoja, Sabine ; Brüggemann, Susanne ; Simbürger, Johann ; Reinders, Jörg ; Riemenschneider, Markus J.


Glioblastoma (GBM) represents the most common and most malignant type of primary brain tumor and significantly contributes to cancer morbidity and mortality. Invasion into the healthy brain parenchyma is a major feature of glioblastoma aggressiveness. Reelin (RELN) is a large secreted extracellular matrix glycoprotein that regulates neuronal migration and positioning in the developing brain and ...


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