| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | European Radiology | ||||
| Verlag: | Springer | ||||
| Ort der Veröffentlichung: | NEW YORK | ||||
| Band: | 28 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 9 | ||||
| Seitenbereich: | S. 3591-3600 | ||||
| Datum: | 2018 | ||||
| Institutionen: | Medizin > Lehrstuhl für Strahlentherapie | ||||
| Identifikationsnummer: |
| ||||
| Stichwörter / Keywords: | HEPATIC-UPTAKE; RELAXATION-TIME; CONTRAST AGENT; MR RELAXOMETRY; LIMAX TEST; CIRRHOSIS; TRANSPLANTATION; HEPATECTOMY; EXPRESSION; FAILURE; Contrast media; Liver diseases; Liver function tests; Breath test; Magnetic resonance imaging | ||||
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 46873 |
Web of ScienceZusammenfassung
To determine whether liver function as determined by intravenous administration of C-13-methacetin and continuous real-time breath analysis can be estimated quantitatively from gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) relaxometry. Sixty-six patients underwent a C-13-methacetin breath test (C-13-MBT) for evaluation of liver function and Gd-EOB-DTPA-enhanced T1-relaxometry at 3 ...
Zusammenfassung
To determine whether liver function as determined by intravenous administration of C-13-methacetin and continuous real-time breath analysis can be estimated quantitatively from gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) relaxometry. Sixty-six patients underwent a C-13-methacetin breath test (C-13-MBT) for evaluation of liver function and Gd-EOB-DTPA-enhanced T1-relaxometry at 3 T. A transverse 3D VIBE sequence with an inline T1 calculation based on variable flip angles was acquired prior to (T1 pre) and 20 min post-Gd-EOB-DTPA (T1 post) administration. The reduction rate of T1 relaxation time (rrT1) and T1 relaxation velocity index (a dagger R1) between pre- and post-contrast images was evaluated. C-13-MBT values were correlated with T1(post), a dagger R1 and rrT1, providing an MRI-based estimated C-13-MBT value. The interobserver reliability was assessed by determining the intraclass correlation coefficient (ICC). Stratified by three different categories of C-13-MBT readouts, there was a constant increase of T1 post with increasing progression of diminished liver function (p <= 0.030) and a constant significant decrease of a dagger R1 (p <= 0.025) and rrT1 (p < 0.018) with progression of liver damage as assessed by C-13-methacetin breath analysis. ICC for all T1 relaxation values and indices was excellent (> 0.88). A simple regression model showed a log-linear correlation of C-13-MBT values with T1(post) (r = 0.57; p < 0.001), a dagger R1 (r = 0.59; p < 0.001) and rrT1 (r = 0.70; p < 0.001). Liver function as determined using real-time C-13-methacetin breath analysis can be estimated quantitatively from Gd-EOB-DTPA-enhanced MR relaxometry. aEuro cent Gd-EOB-DTPA-enhanced T1 relaxometry quantifies liver function aEuro cent Gd-EOB-DTPA-enhanced MR relaxometry may provide parameters for assessing liver function before surgery aEuro cent Gd-EOB-DTPA-enhanced MR relaxometry may be useful for monitoring liver disease progression aEuro cent Gd-EOB-DTPA-enhanced MR relaxometry has the potential to become a novel liver function index.
Metadaten zuletzt geändert: 28 Jul 2021 17:08
Altmetric