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Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet

Aspichueta, Patricia ; Cairns, Rose ; Fischer, Alexander W. ; Blanco-Munoz, Patricia ; Alvarez-Guaita, Anna ; Meneses-Salas, Elsa ; Egert, Antonia ; Buechler, Christa ; Hoy, Andrew J. ; Heeren, Joerg ; Enrich, Carlos ; Rentero, Carles ; Grewal, Thomas


Annexin A6 (AnxA6) controls cholesterol and membrane transport in endo- and exocytosis, and modulates triglyceride accumulation and storage. In addition, AnxA6 acts as a scaffolding protein for negative regulators of growth factor receptors and their effector pathways in many different cell types. Here we investigated the role of AnxA6 in the regulation of whole body lipid metabolism and ...


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