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Association of Genetic Variants With Response to Anti–Vascular Endothelial Growth Factor Therapy in Age-Related Macular Degeneration

Lorés-Motta, Laura ; Riaz, Moeen ; Grunin, Michelle ; Corominas, Jordi ; van Asten, Freekje ; Pauper, Marc ; Leenders, Mathieu ; Richardson, Andrea J. ; Muether, Philipp ; Cree, Angela J. ; Griffiths, Helen L. ; Pham, Connie ; Belanger, Marie-Claude ; Meester-Smoor, Magda A. ; Ali, Manir ; Heid, Iris M. ; Fritsche, Lars G. ; Chakravarthy, Usha ; Gale, Richard ; McKibbin, Martin ; Inglehearn, Chris F. ; Schlingemann, Reinier O. ; Omar, Amer ; Chen, John ; Koenekoop, Robert K. ; Fauser, Sascha ; Guymer, Robyn H. ; Hoyng, Carel B. ; de Jong, Eiko K. ; Lotery, Andrew J. ; Mitchell, Paul ; den Hollander, Anneke I. ; Baird, Paul N. ; Chowers, Itay



Abstract

IMPORTANCE Visual acuity (VA) outcomes differ considerably among patients with neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor (VEGF) drugs. Identification of pharmacogenetic associations may help clinicians understand the mechanisms underlyingthis variability as well as pave the way for personalized treatment in nAMD. OBJECTIVE To identify ...

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