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High CDKN2A/p16 and Low FGFR3 Expression Predict Progressive Potential of Stage pT1 Urothelial Bladder Carcinoma

Breyer, Johannes ; Wirtz, Ralph M. ; Erben, Philipp ; Worst, Thomas S. ; Stoehr, Robert ; Eckstein, Markus ; Bertz, Simone ; Sikic, Danijel ; Denzinger, Stefan ; Burger, Maximilian ; Hartmann, Arndt ; Otto, Wolfgang ; Breyer, Johannes ; Wirtz, Ralph M. ; Erben, Philipp ; Worst, Thomas S. ; Stoehr, Robert ; Eckstein, Markus ; Sikic, Danijel ; Burger, Maximilian ; Hartmann, Arndt ; Otto, Wolfgang



Abstract

Identifying pT1 bladder cancer with high risk for progression remains a challenge. Aberrations in cyclin-dependent kinase inhibitor 2A (CDKN2A)/p16 and fibroblast growth factor receptor 3 (FGFR3) expression are the most common in urothelial bladder cancer. In the study at hand, we could show that high CDKN2A/p16 mRNA expression is associated with the luminal subtype and high CDKN2A/p16 as well as ...

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