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LIN28 Selectively Modulates a Subclass of Let-7 MicroRNAs

Ustianenko, Dmytro ; Chiu, Hua-Sheng ; Treiber, Thomas ; Weyn-Vanhentenryck, Sebastien M. ; Treiber, Nora ; Meister, Gunter ; Sumazin, Pavel ; Zhang, Chaolin


LIN28 is a bipartite RNA-binding protein that posttranscriptionallyinhibits the biogenesis of let-7 microRNAs to regulate development and influence disease states. However, the mechanisms of let-7 suppression remain poorly understood because LIN28 recognition depends on coordinated targeting by both the zinc knuckle domain (ZKD), which binds a GGAG-like element in the precursor, and the cold ...


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