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Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia

Rothenberg-Thurley, Maja ; Amler, Susanne ; Goerlich, Dennis ; Köhnke, Thomas ; Konstandin, Nikola P. ; Schneider, Stephanie ; Sauerland, Maria C. ; Herold, Tobias ; Hubmann, Max ; Ksienzyk, Bianka ; Zellmeier, Evelyn ; Bohlander, Stefan K. ; Subklewe, Marion ; Faldum, Andreas ; Hiddemann, Wolfgang ; Braess, Jan ; Spiekermann, Karsten ; Metzeler, Klaus H.



Abstract

Some patients with acute myeloid leukemia (AML) who are in complete remission after induction chemotherapy harbor persisting pre-leukemic clones, carrying a subset of leukemia-associated somatic mutations. There is conflicting evidence on the prognostic relevance of these clones for AML relapse. Here, we characterized paired pre-treatment and remission samples from 126 AML patients for mutations ...

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