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Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8

Billot, Katy ; Coquil, Charlène ; Villiers, Benoit ; Josselin-Foll, Béatrice ; Desban, Nathalie ; Delehouzé, Claire ; Oumata, Nassima ; Le Meur, Yannick ; Boletta, Alessandra ; Weimbs, Thomas ; Grosch, Melanie ; Witzgall, Ralph ; Saunier, Sophie ; Fischer, Evelyne ; Pontoglio, Marco ; Fautrel, Alain ; Mrug, Michal ; Wallace, Darren ; Tran, Pamela V. ; Trudel, Marie ; Bukanov, Nikolay ; Ibraghimov-Beskrovnaya, Oxana ; Meijer, Laurent



Abstract

Following the discovery of (R)-roscovitine's beneficial effects in three polycystic kidney disease (PKD) mouse models, cyclin-dependent kinases (CDKs) inhibitors have been investigated as potential treatments. We have used various affinity chromatography approaches to identify the molecular targets of roscovitine and its more potent analog (S)-CR8 in human and murine polycystic kidneys. These ...

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