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Cellular Origin and Functional Relevance of Collagen I Production in the Kidney

Buchtler, Simone ; Grill, Alexandra ; Hofmarksrichter, Stefanie ; Stöckert, Petra ; Schiechl-Brachner, Gabriela ; Rodriguez Gomez, Manuel ; Neumayer, Sophia ; Schmidbauer, Kathrin ; Talke, Yvonne ; Klinkhammer, Barbara M. ; Boor, Peter ; Medvinsky, Alexander ; Renner, Kerstin ; Castrop, Hayo ; Mack, Matthias


Background Interstitial fibrosis is associated with chronic renal failure. In addition to fibroblasts, bone marrow-derived cells and tubular epithelial cells have the capacity to produce collagen. However, the amount of collagen produced by each of these cell types and the relevance of fibrosis to renal function are unclear. Methods We generated conditional cell type-specific collagen I knockout ...


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