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MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD

Major-Monfried, Hannah ; Renteria, Anne S. ; Pawarode, Attaphol ; Reddy, Pavan ; Ayuk, Francis ; Holler, Ernst ; Efebera, Yvonne A. ; Hogan, William J. ; Wölfl, Matthias ; Qayed, Muna ; Hexner, Elizabeth O. ; Wudhikarn, Kitsada ; Ordemann, Rainer ; Young, Rachel ; Shah, Jay ; Hartwell, Matthew J. ; Chaudhry, Mohammed S. ; Aziz, Mina ; Etra, Aaron ; Yanik, Gregory A. ; Kröger, Nicolaus ; Weber, Daniela ; Chen, Yi-Bin ; Nakamura, Ryotaro ; Rösler, Wolf ; Kitko, Carrie L. ; Harris, Andrew C. ; Pulsipher, Michael ; Reshef, Ran ; Kowalyk, Steven ; Morales, George ; Torres, Ivan ; Özbek, Umut ; Ferrara, James L. M. ; Levine, John E.



Zusammenfassung

Acute graft-versus-host disease (GVHD) is treated with systemic corticosteroid immuno- suppression. Clinical response after 1 week of therapy often guides further treatment decisions, but long-term outcomes vary widely among centers, and more accurate predictive tests are urgently needed. We analyzed clinical data and blood samples taken 1 week after systemic treatment of GVHD from 507 patients ...

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