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p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget’s disease–like bone phenotypes in mice

Zach, Frank ; Polzer, Franziska ; Mueller, Alexandra ; Gessner, André



Zusammenfassung

The sequestosome 1 gene encodes the p62 protein and is the major genetic risk factor associated with Paget's disease of bone. In 2004, p62 was reported to up-regulate osteoclast differentiation by activating the transcription factors Nfatc1 and NF-B. Here, we characterized the osteoclastogenic potential of murine p62(-/-)-derived cells compared with WT cells. Our data confirmed previous findings ...

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