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The tumor-inhibiting effect of diethylstilbestrol-3,4-oxide

Schneider, M. R. ; Kranzfelder, G. ; Angerer, E. von ; Schönenberger, H. ; Metzler, M. ; Michel, R. T. ; Fortmeyer, H. P. ; Ruckdeschel, G.


Diethylstilbestrol-3,4-oxide, (DES-3,4-oxide), one of the possible cancerogenic metabolites of the well-known estrogen diethylstilbestrol (DES), is a potential estrophilic cytostatic compound. It shows a very good affinity to the estrogen receptor. The uterotrophic activity determined in the mouse uterine weight bioassay is nearly identical with that of DES. Potential alkylating properties could ...


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