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3,4-bis(3'-hydroxyphenyl)hexane--a new mammary tumor-inhibiting compound

Kranzfelder, G. ; Hartmann, R. W. ; Angerer, E. von ; Schönenberger, H. ; Bogden, A. E.



Abstract

The syntheses of the hexestrol derivatives 3,4-bis-(3'-hydroxyphenyl)hexane (4a), 3,4-bis(4'-fluoro-3'-hydroxyphenyl)hexane (4b), 3,4-bis(3',4'dihydroxyphenyl)hexane (4c), and 3,4-bis(3',4'-diacetoxyphenyl)hexane (4d) are described. All compounds showed a marked, competitive inhibition of the estradiol receptor interaction (Ka4c greater than Ka4a greater than Ka4d greater than Ka4b). Evaluated in ...

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