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1,1,2-triphenylbut-1-enes: relationship between structure, estradiol receptor affinity, and mammary tumor inhibiting properties

Schneider, M. R., Angerer, E. von, Schönenberger, H., Michel, R. T. and Fortmeyer, H. P. (1982) 1,1,2-triphenylbut-1-enes: relationship between structure, estradiol receptor affinity, and mammary tumor inhibiting properties. Journal of medicinal chemistry 25 (9), pp. 1070-7.

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Abstract

1,1,2-Triphenylbut-1-enes, which are substituted with acetoxy groups on one, two, or three aromatic rings in the para and/or meta positions, were synthesized. The identity of the occurring E and Z isomers were established by 1H NMR spectroscopy. A study on structure-activity relationships was carried out with regard to estradiol receptor affinity and to inhibiting effects on the growth of a ...

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Item type:Article
Date:1982
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
6813499PubMed ID
Classification:
NotationType
9,10-Dimethyl-1,2-benzanthracene/toxicityMESH
Alkenes/chemical synthesisMESH
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
ChemistryMESH
FemaleMESH
Mammary Neoplasms, Experimental/chemically inducedMESH
MiceMESH
Mice, NudeMESH
Neoplasm TransplantationMESH
RatsMESH
Receptors, EstradiolMESH
Receptors, Estrogen/metabolismMESH
Structure-Activity RelationshipMESH
Time FactorsMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:4718
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