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Deletion of NLRX1 increases fatty acid metabolism and prevents diet-induced hepatic steatosis and metabolic syndrome

Kors, Lotte ; Rampanelli, Elena ; Stokman, Geurt ; Butter, Loes M. ; Held, Ntsiki M. ; Claessen, Nike ; Larsen, Per W.B. ; Verheij, Joanne ; Zuurbier, Coert J. ; Liebisch, Gerhard ; Schmitz, Gerd ; Girardin, Stephen E. ; Florquin, Sandrine ; Houtkooper, Riekelt H. ; Leemans, Jaklien C.



Abstract

NOD-like receptor (NLR)X1 (NLRX1) is an ubiquitously expressed inflammasome-independent NLR that is uniquely localized in mitochondria with as yet unknown effects on metabolic diseases. Here, we report that NLRX1 is essential in regulating cellular metabolism in non-immune parenchymal hepatocytes by decreasing mitochondrial fatty acid-dependent oxidative phosphorylation (OXPHOS) and promoting ...

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