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Benzylamines: synthesis and evaluation of antimycobacterial properties

Meindl, Wolfgang R. ; Angerer, Erwin von ; Schönenberger, Helmut ; Ruckdeschel, Gotthard



Abstract

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (19, MIC 10.2 micrograms/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 micrograms/mL), and N-butyl-3,5-difluorobenzylamine (103, MIC 6.4 ...

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