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Inhibition of amyloid Aβ aggregation by high pressures or specificd-enantiomeric peptides

Cavini, Italo A. ; Munte, Claudia E. ; Erlach, Markus Beck ; van Groen, Thomas ; Kadish, Inga ; Zhang, Tao ; Ziehm, Tamar ; Nagel-Steger, Luitgard ; Kutzsche, Janine ; Kremer, Werner ; Willbold, Dieter ; Kalbitzer, Hans Robert



Abstract

Pressure can shift the polymer-monomer equilibrium of A beta, increasing pressure first leads to a release of A beta-monomers, surprisingly at pressures higher than 180 MPa repolymerization is induced. By high pressure NMR spectroscopy, differences of partial molar volumes Delta V-0 and compressibility factors Delta beta' of polymerization were determined at different temperatures. The ...

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