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Molecular Mechanisms of Biased and Probe-Dependent Signaling at CXC-Motif Chemokine Receptor CXCR3 Induced by Negative Allosteric Modulators

Brox, Regine ; Milanos, Lampros ; Saleh, Noureldin ; Baumeister, Paul ; Buschauer, Armin ; Hofmann, Dagmar ; Heinrich, Markus R. ; Clark, Timothy ; Tschammer, Nuska


Our recent explorations of allosteric modulators with improved properties resulted in the identification of two biased negative allosteric modulators, BD103 (N-1-{[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrinni-din2yl]ethyl}-4-(4-fluorobutoxy)-N-[(1 -methylpiperidin-4-yl)methyl}]butanannide) and BD064 ...


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