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Studies on the mammary tumor-inhibiting effects of diethylstilbestrol and its mono- and diphosphate

Schneider, M. R. ; Angerer, E. von ; Prekajac, J. ; Brade, W. P.



Abstract

Diethylstilbestrol (DES), diethylstilbestrol monophosphate (DES-MP) and diethylstilbestrol diphosphate (DES-DP) were tested for their estrogen receptor affinity, estrogenic potency and mammary tumor-inhibiting activity in vitro and in vivo. DES had a much higher receptor binding affinity than its mono- or diphosphate. All three compounds inhibited the growth of the hormone-dependent MCF-7 and ...

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