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Antitumor activity of antiestrogenic phenylindoles on experimental prostate tumors

Schneider, M. R. ; Angerer, E. von ; Höhn, W. ; Sinowatz, F.


Two antiestrogenic phenylindoles (D 16726 and D 15413) were tested for their prostatic tumor-inhibiting activity. Both compounds exerted a strong inhibitory effect on prostate and seminal vesicle weight of intact rats and mice comparable to that of diethylstilbestrol. Their estrogenic properties, however, are much lower than those of DES. Therefore, there is no direct correlation between ...


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