Koch, M. ; Utpatel, K. ; Schulz, C.
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Der Internist |
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| Verlag: | Springer |
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| Ort der Veröffentlichung: | NEW YORK |
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| Band: | 59 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 4 |
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| Seitenbereich: | S. 384-387 |
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| Datum: | 2018 |
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| Institutionen: | Medizin > Lehrstuhl für Innere Medizin II |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1007/s00108-017-0321-1 | DOI |
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| Stichwörter / Keywords: | TRANSFORMATION; CANCER; Non-small-cell lung cancer; Small-cell lung cancer; Tyrosine kinase inhibitor; Afatinib; Biopsy |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 47342 |
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Web of Science
Zusammenfassung
The case of a 58-year old female patient with epidermal growth factor-positive pulmonary adenocarcinoma treated with the tyrosine kinase inhibitor afatinib is reported. After several months of first-line therapy the patient developed severe hyponatremia and tumor reassessment revealed a progressive course of the lung cancer. Rebiopsy showed transformation of the tumor into small-cell lung cancer. ...
Zusammenfassung
The case of a 58-year old female patient with epidermal growth factor-positive pulmonary adenocarcinoma treated with the tyrosine kinase inhibitor afatinib is reported. After several months of first-line therapy the patient developed severe hyponatremia and tumor reassessment revealed a progressive course of the lung cancer. Rebiopsy showed transformation of the tumor into small-cell lung cancer. Therapy with afatinib was stopped immediately and platin-based chemotherapy was started. This case shows that tumor transformation under tyrosine kinase inhibitor therapy from non-small-cell into small-cell lung cancer can occur in rare cases.
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