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Clinical validation of a novel enzyme-linked immunosorbent spot assay-basedin vitrodiagnostic assay to monitor cytomegalovirus-specific cell-mediated immunity in kidney transplant recipients: a multicenter, longitudinal, prospective, observational study

Banas, Bernhard ; Steubl, Dominik ; Renders, Lutz ; Chittka, Dominik ; Banas, Miriam C. ; Wekerle, Thomas ; Koch, Martina ; Witzke, Oliver ; Mühlfeld, Anja ; Sommerer, Claudia ; Habicht, Antje ; Hugo, Christian ; Hünig, Thomas ; Lindemann, Monika ; Schmidt, Traudel ; Rascle, Anne ; Barabas, Sascha ; Deml, Ludwig ; Wagner, Ralf ; Krämer, Bernhard K. ; Krüger, Bernd


Impaired cytomegalovirus (CMV)-specific cell-mediated immunity (CMV-CMI) is a major cause of CMV reactivation and associated complications in solid-organ transplantation. Reliably assessing CMV-CMI is desirable to individually adjust antiviral and immunosuppressive therapy. This study aimed to evaluate the suitability of T-Track((R)) CMV, a novel IFN- ELISpot assay based on the stimulation of ...


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