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Carrier mediated action of platinum complexes on estrogen receptor positive tumors

Knebel, N. ; Schiller, C. D. ; Schneider, M. R. ; Schönenberger, H. ; Angerer, E. von


Three 1,2-diaminoethane-dichloro-platinum(II) complexes linked to 5-hydroxy-2-(4-hydroxyphenyl)-3-methylindole by spacer groups of varying length were evaluated for cytostatic activity in estrogen receptor (ER) positive and negative tumor cells. In vitro, only the growth of ER positive MCF-7 mammary tumor cells was inhibited whereas hormone independent MDA-MB 231 cells did not respond. In vivo, a ...


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