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High PDL1 mRNA expression predicts better survival of stage pT1 non-muscle-invasive bladder cancer (NMIBC) patients

Breyer, Johannes ; Wirtz, Ralph M. ; Otto, Wolfgang ; Erben, Philipp ; Worst, Thomas S. ; Stoehr, Robert ; Eckstein, Markus ; Denzinger, Stefan ; Burger, Maximilian ; Hartmann, Arndt


Introduction and objectives Checkpoint inhibition has emerged as new therapeutic option in muscle-invasive bladder cancer. The objective of the present study was to evaluate the prognostic role of PD1 and PDL1 expression in non-muscle-invasive bladder cancer (NMIBC) and establish an objective measuring method using RNA quantification. Materials and methods We retrospectively analyzed clinical ...


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