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The adherens junction–associated LIM domain protein Smallish regulates epithelial morphogenesis

Beati, Hamze ; Peek, Irina ; Hordowska, Paulina ; Honemann-Capito, Mona ; Glashauser, Jade ; Renschler, Fabian A. ; Kakanj, Parisa ; Ramrath, Andreas ; Leptin, Maria ; Luschnig, Stefan ; Wiesner, Silke ; Wodarz, Andreas


In epithelia, cells adhere to each other in a dynamic fashion, allowing the cells to change their shape and move along each other during morphogenesis. The regulation of adhesion occurs at the belt-shaped adherens junction, the zonula adherens (ZA). Formation of the ZA depends on components of the Par-atypical PKC (Par-aPKC) complex of polarity regulators. We have identified the Lin11, Isl-1, ...


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