Schiller, Claus D., Schneider, Martin R. and Angerer, Erwin von (1990) 3-(Cyclohexenonyl)-4-(4-hydroxyphenyl)-hexanes: antiandrogenes derived from the estrogen hexestrol. Archiv der Pharmazie 323 (7), pp. 417-420.
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Abstract
Selective Birch-reduction of one of the phenolic rings of meso- or d,l-HES led to compounds 6a and 6b which exert a higher binding affinity to the androgen receptor as the respective parent HES. In vivo testing of 6a and 6b shows that 6a has the same potency in reducing accessory sex organ weights and testosterone levels in the intact mouse as has meso-HES, but strongly decreased estrogenic ...
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| Item type: | Article | ||||||||||||||||||||||
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| Date: | 1990 | ||||||||||||||||||||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) | ||||||||||||||||||||||
| Projects: | SFB 234 | ||||||||||||||||||||||
| Identification Number: |
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| Classification: |
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| Dewey Decimal Classification: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||
| Refereed: | Yes, this version has been refereed | ||||||||||||||||||||||
| Created at the University of Regensburg: | Yes | ||||||||||||||||||||||
| Item ID: | 4743 |
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