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CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism

García-Rodríguez, Sonia ; Rosal-Vela, Antonio ; Botta, Davide ; Cumba Garcia, Luz M. ; Zumaquero, Esther ; Prados-Maniviesa, Verónica ; Cerezo-Wallis, Daniela ; Lo Buono, Nicola ; Robles-Guirado, José-Ángel ; Guerrero, Salvador ; González-Paredes, Elena ; Andrés-León, Eduardo ; Corbí, Ángel ; Mack, Matthias ; Koch-Nolte, Friedrich ; Merino, Ramón ; Zubiaur, Mercedes ; Lund, Frances E. ; Sancho, Jaime


In this study, we investigated the role of CD38 in a pristane-induced murine model of lupus. CD38-deficient (Cd38(-/-)) but not ART2-deficient (Art2(-/-)) mice developed less severe lupus compared to wild type (WT) mice, and their protective phenotype consisted of (i) decreased IFN-I-stimulated gene expression, (ii) decreased numbers of peritoneal CCR2(hi)Ly6C(hi) inflammatory monocytes, ...


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