2-Phenylbenzo[b]furans: relationship between structure, estrogen receptor affinity and cytostatic activity against mammary tumor cells

Erber, S., Ringshandl, R. und Angerer, E. von (1991) 2-Phenylbenzo[b]furans: relationship between structure, estrogen receptor affinity and cytostatic activity against mammary tumor cells. Anti-cancer drug design 6 (5), S. 417-426.

Im Publikationsserver gibt es leider keinen Volltext zu diesem Eintrag.

Zum PubMed-Eintrag dieses Artikels

Zusammenfassung

A number of 2-(4-hydroxyphenyl)benzo[b]furans with a hydroxy group in position 5 or 6 and a short alkyl group at C-3 were synthesized from appropriate 1,2-diarylethanones and studied for their estrogen receptor affinity. The relative binding affinities in the 5-hydroxy series were higher than those of 6-hydroxy derivatives by a factor of 10. The trifluoroethyl and the propyl derivatives displayed ...

Bibliographische Daten exportieren