Go to content
UR Home

Pharmacological characterization of a novel oestrogen antagonist, ZK 119010, in rats and mice

Nishino, Y. ; Schneider, M. R. ; Michna, H. ; Angerer, E. von



Abstract

The oestrogenic and antioestrogenic effects of a new nonsteroidal compound ZK 119010 (2-(4-hydroxyphenyl)-3-methyl-1-[6-(1-pyrrolidinyl)-hexyl]-indol-5-ol) were evaluated and compared with those of tamoxifen and ICI 164384. In immature mice, ZK 119010 administered once daily for 3 days (s.c.) inhibited the uterotrophic and vaginotrophic effect of oestradiol in a dose-dependent manner and was ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons