| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Sleep Medicine | ||||
| Publisher: | ELSEVIER SCIENCE BV | ||||
| Place of Publication: | AMSTERDAM | ||||
| Volume: | 42 | ||||
| Page Range: | pp. 13-20 | ||||
| Date: | 2018 | ||||
| Institutions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien | ||||
| Identification Number: |
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| Keywords: | ELEVATION MYOCARDIAL-INFARCTION; TP-E/QT RATIO; QT INTERVAL; HEART-FAILURE; PROGNOSTIC IMPLICATIONS; RECORDING DEVICE; APNEA; DISEASE; APNEALINK(TM); PREVALENCE; Sleep apnea; TpTe; QT; Cardiac repolarization; Cardiac arrhythmias; Coronary artery bypass graft surgery | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 47505 |
Web of ScienceAbstract
Background: The development of malignant ventricular arrhythmias due to abnormal cardiac repolarization is a major complication after coronary artery bypass graft surgery (CABG). Sleep-disordered breathing (SDB) is linked to prolonged cardiac repolarization in non-surgical patients. This study evaluates cardiac repolarization in patients with and without SDB who underwent CABG. Methods: 100 ...
Abstract
Background: The development of malignant ventricular arrhythmias due to abnormal cardiac repolarization is a major complication after coronary artery bypass graft surgery (CABG). Sleep-disordered breathing (SDB) is linked to prolonged cardiac repolarization in non-surgical patients. This study evaluates cardiac repolarization in patients with and without SDB who underwent CABG. Methods: 100 patients who had received CABG (84% men, age 68 +/- 10 years, body-mass-index [BMI] 28.7 +/- 4.2 kg/m(2)) were retrospectively evaluated. Polygraphy was recorded the night before CABG. SDB was defined as an apnea-hypopnea index (AHI) of >= 15/h and differentiated into central (CSA) and obstructive (OSA) sleep apnea. Cardiac repolarizationwas assessed by means of T-peak-to-end (TpTe) and QTc-intervals and TpTe/QT-ratios derived from 12-lead electrocardiography (ECG). Results: 37% of patients had SDB, 14% CSA and 23% OSA. Before CABG, patients with CSA and OSA had longer TpTe intervals than those without SDB (TpTe: CSA 100 +/- 26 vs. OSA 97 +/- 19 vs. no SDB 85 +/- 14 ms, p = 0.013). QTc intervals and TpTe/QT ratios differed between the two groups (QTc: 444 +/- 54 vs. 462 +/- 36 vs. 421 +/- 32 ms, p < 0.001; TpTe/QT ratio: 0.24 +/- 0.04 vs. 0.23 +/- 0.05 vs. 0.21 +/- 0.03, p = 0.045). SDB was associated with abnormal cardiac repolarization independent of known risk factors for cardiac arrhythmias, such as age, sex, BMI, N-terminal-pro-brain-natriuretic-peptide (NT-proBNP), and heart failure (TpTe: B-coefficient [95%-CI]: 16.0, [7.6-24.3], p < 0.001; QTc: 27.2 [9.3-45.1], p = 0.003; TpTe/QT ratio: 2.9 [1.2-4.6], p < 0.001). Conclusion: Independent of known risk factors for cardiac arrhythmias, SDB was significantly associated with abnormal cardiac repolarization before CABG. Data suggest that SDB may contribute to an increased risk of ventricular arrhythmias after CABG. (c) 2018 Elsevier B.V. All rights reserved.
Metadata last modified: 28 Jul 2021 17:23
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