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Effect of zindoxifene on experimental prostatic tumours of the rat

Schneider, M. R. ; Schiller, C. D. ; Humm, A. ; Angerer, E. von



Abstract

The anti-oestrogen zindoxifene was originally developed as a drug for the treatment of hormone-dependent mammary carcinomas. Experiments with rats bearing androgen-dependent prostatic tumours revealed anti-neoplastic activity of zindoxifene on these tumours also. Therefore, the inhibitory effect of this drug was studied in various prostatic tumour models in comparison to the anti-oestrogen ...

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