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Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage

Chang, Che-Feng ; Goods, Brittany A. ; Askenase, Michael H. ; Hammond, Matthew D. ; Renfroe, Stephen C. ; Steinschneider, Arthur F. ; Landreneau, Margaret J. ; Ai, Youxi ; Beatty, Hannah E. ; da Costa, Luís Henrique Angenendt ; Mack, Matthias ; Sheth, Kevin N. ; Greer, David M. ; Huttner, Anita ; Coman, Daniel ; Hyder, Fahmeed ; Ghosh, Sourav ; Rothlin, Carla V. ; Love, J. Christopher ; Sansing, Lauren H.


Macrophages are a source of both proinflammatory and restorative functions in damaged tissue through complex dynamic phenotypic changes. Here, we sought to determine whether monocyte-derived macrophages (MDMs) contribute to recovery after acute sterile brain injury. By profiling the transcriptional dynamics of MDMs in the murine brain after experimental intracerebral hemorrhage (ICH), we found ...


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