Go to content
UR Home

A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic

Lérias, Joana R. ; Pinto, Madalena C. ; Botelho, Hugo M. ; Awatade, Nikhil T. ; Quaresma, Margarida C. ; Silva, Iris A.L. ; Wanitchakool, Podchanart ; Schreiber, Rainer ; Pepperkok, Rainer ; Kunzelmann, Karl ; Amaral, Margarida D.


An attractive possibility to treat Cystic Fibrosis (CF), a severe condition caused by dysfunctional CFTR, an epithelial anion channel, is through the activation of alternative (non-CFTR) anion channels. Anoctamin 1 (ANO1) was demonstrated to be a Ca2+-activated chloride channel (CaCC) and thus of high potential to replace CFTR. Despite that ANO1 is expressed in human lung CF tissue, it is present ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons