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Dunning R3327-G prostate carcinoma of the rat: an appropriate model for drug evaluation

Kager, M. ; Spruss, T. ; Schneider, M. R. ; Angerer, E. von



Abstract

Models for testing new drugs for the treatment of hormone-dependent prostate cancer are restricted to a few in vivo rat tumour lines; most of them originating from the Dunning R3327 adenocarcinoma. The original tumour and the R3327-H line grow rather slowly leading to a long duration of therapeutic experiments. The R3327-G subline can be transplanted as a cell suspension or tumour fragments, ...

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