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Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+and plasma membrane lipid

Schreiber, Rainer ; Ousingsawat, Jiraporn ; Wanitchakool, Podchanart ; Sirianant, Lalida ; Benedetto, Roberta ; Reiss, Karina ; Kunzelmann, Karl


TMEM16/anoctamin (ANO) proteins form Ca2+-activated ion channels or phospholipid scramblases. We found that both TMEM16A/ANO1 and TMEM16F/ANO6 produced Cl- currents when activated by intracellular Ca2+, but only TMEM16F was able to expose phosphatidylserine to the outer leaflet of the plasma membrane. Mutations within TMEM16F or TMEM16A/F chimeras similarly changed Cl- currents and phospholipid ...


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