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Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection

Campbell, Sharon M. ; Knipper, Johanna A. ; Ruckerl, Dominik ; Finlay, Conor M. ; Logan, Nicola ; Minutti, Carlos M. ; Mack, Matthias ; Jenkins, Stephen J. ; Taylor, Matthew D. ; Allen, Judith E.


Both T(H)2-dependent helminth killing and suppression of the T(H)2 effector response have been attributed to macrophages (M Phi) activated by IL-4 (M(IL-4)). To investigate how M(IL-4) contribute to diverse infection outcomes, the MO compartment of susceptible BALB/c mice and more resistant C57BL/6 mice was profiled during infection of the pleural cavity with the filarial nematode, Litomosoides ...


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