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Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours

Maucher, A. ; Angerer, E. von



Abstract

The nonsteroidal antiandrogen casodex has been described as a peripherally selective drug for the treatment of prostatic cancer. In this study we determined its activity in various models of hormone-dependent malignancies including those of the prostate and the breast. Analysis of endocrine effects in rats after 15 days of treatment revealed a strong reduction of the weights of prostates and ...

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