Dokumentenart: | Artikel | ||||
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Titel eines Journals oder einer Zeitschrift: | Nature Genetics | ||||
Verlag: | Nature | ||||
Ort der Veröffentlichung: | NEW YORK | ||||
Band: | 50 | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 1 | ||||
Seitenbereich: | S. 42-53 | ||||
Datum: | 2018 | ||||
Institutionen: | Medizin > Lehrstuhl für Kinder- und Jugendmedizin | ||||
Identifikationsnummer: |
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Stichwörter / Keywords: | GENOME-WIDE ASSOCIATION; AUTOIMMUNE-DISEASE; HAY-FEVER; VARIANTS; METAANALYSIS; EXPRESSION; GENE; POPULATIONS; TWINS; | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 47614 |
Zusammenfassung
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of ...
Zusammenfassung
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
Metadaten zuletzt geändert: 28 Jul 2021 17:26