Item type: | Article | ||||
---|---|---|---|---|---|
Journal or Publication Title: | Urologia Internationalis | ||||
Publisher: | KARGER | ||||
Place of Publication: | BASEL | ||||
Volume: | 101 | ||||
Number of Issue or Book Chapter: | 1 | ||||
Page Range: | pp. 16-24 | ||||
Date: | 2018 | ||||
Institutions: | Medicine > Lehrstuhl für Urologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien | ||||
Identification Number: |
| ||||
Keywords: | WORSE ONCOLOGICAL OUTCOMES; BLADDER-CANCER; BLOOD-LOSS; OBESITY; IMPACT; MORTALITY; RISK; CARCINOMA; COHORT; Urothelial carcinoma; Bladder cancer; Obesity; Radical cystectomy; Prognosis; Survival | ||||
Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
Status: | Published | ||||
Refereed: | Yes, this version has been refereed | ||||
Created at the University of Regensburg: | Yes | ||||
Item ID: | 47622 |
Abstract
Background/Aims/Objectives: To evaluate the influence of body mass index (BMI) on complications and oncological outcomes in patients undergoing radical cystectomy (RC). Methods: Clinical and histopathological parameters of pa-tients have been prospectively collected within the "PRO-spective MulticEnTer RadIcal Cystectomy Series 2011". BMI was categorized as normal weight (< 25 kg/m(2)), ...
Abstract
Background/Aims/Objectives: To evaluate the influence of body mass index (BMI) on complications and oncological outcomes in patients undergoing radical cystectomy (RC). Methods: Clinical and histopathological parameters of pa-tients have been prospectively collected within the "PRO-spective MulticEnTer RadIcal Cystectomy Series 2011". BMI was categorized as normal weight (< 25 kg/m(2)), overweight (>= 25-29.9 kg/m(2)) and obesity (>= 30 kg/m(2)). The association between BMI and clinical and histopathological endpoints was examined. Ordinal logistic regression models were applied to assess the influence of BMI on complication rate and survival. Results: Data of 671 patients were eligible for final analysis. Of these patients, 26% (n = 175) showed obesity. No significant association of obesity on tumour stage, grade, lymph node metastasis, blood loss, type of urinary diversion and 90-day mortality rate was found. According to the American Society of Anesthesiologists score, local lymph node (NT) stage and operative case load patients with higher BMI had significantly higher probabilities of severe complications 30 days after RC (p = 0.037). The overall survival rate of obese patients was superior to normal weight patients (p = 0.019). Conclusions: There is no evidence of correlation between obesity and worse oncological outcomes after RC. While obesity should not be a parameter to exclude patients from cystectomy, surgical settings need to be aware of higher short-term complication risks and obese patients should be counselled - accordingly. (C) 2018 S. Karger AG, Basel
Metadata last modified: 28 Jul 2021 17:26