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Fluorescein-Guided Surgery for Resection of High-Grade Gliomas: A Multicentric Prospective Phase II Study (FLUOGLIO)

Acerbi, Francesco ; Broggi, Morgan ; Schebesch, Karl-Michael ; Höhne, Julius ; Cavallo, Claudio ; De Laurentis, Camilla ; Eoli, Marica ; Anghileri, Elena ; Servida, Maura ; Boffano, Carlo ; Pollo, Bianca ; Schiariti, Marco ; Visintini, Sergio ; Montomoli, Cristina ; Bosio, Lorenzo ; La Corte, Emanuele ; Broggi, Giovanni ; Brawanski, Alexander ; Ferroli, Paolo



Abstract

Purpose: Sodium fluorescein is a dye that, intravenously injected, selectively accumulates in high-grade glioma (HGG) tissue through a damaged blood-brain barrier. In this article, the final results of a multicentric prospective phase II trial (FLUOGLIO) on fluorescein-guided HGG resection through a dedicated filter on the surgical microscope were reported. Methods: Patients with suspected HGGs ...

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