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Adipose tissue-derived stem cells from affected and unaffected areas in patients with multiple symmetric lipomatosis show differential regulation of mTOR pathway genes

Felthaus, Oliver ; Schön, Teresa ; Schiltz, Daniel ; Aung, Thiha ; Kühlmann, Britta ; Jung, Friedrich ; Anker, Alexandra ; Klein, Silvan ; Prantl, Lukas



Abstract

BACKGROUND: Multiple symmetric lipomatosis is a rare disease characterized by the excessive growth of uncapsulated masses of adipose tissue. Although the etiology has yet to be elucidated, a connection to brown adipose tissue has been proposed recently. The mTOR pathway which is found to be regulated in lipomatous tissue as well as associated with brown adipose tissue can be inhibited by a ...

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