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Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork

Aktas, Zeynep ; Rao, Hongyu ; Slauson, Sarah R. ; Gabelt, B'Ann T. ; Larsen, Inna V. ; Sheridan, Rachael T. C. ; Herrnberger, Leonie ; Tamm, Ernst R. ; Kaufman, Paul L. ; Brandt, Curtis R.



Abstract

PURPOSE: To determine if proteasome inhibition using MG132 increased the efficiency of FIV vector-mediated transduction in human trabecular meshwork (TM)-1 cells and monkey organ-cultured anterior segments (MOCAS). METHODS: TM-1 cells were pretreated for 1 hour with 0.5% dimethyl sulfoxide (DMSO; vehicle control) or 5 to 50 mu M MG132 and transduced with FIV.GFP (green fluorescent protein)- or ...

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