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Effect of growth factors on estrogen receptor mediated gene expression

Hafner, F. ; Holler, E. ; Angerer, E. von


The proliferation of mammary carcinoma cells can be stimulated by estrogens and various growth factors such as EGF and IGF-I. Steroid hormones and growth factors are understood to exert their effects via different receptors and signal transduction pathways. Recently, it has been shown that growth factors can utilize the unliganded estrogen receptor (ER) as a transcription factor. This study was ...


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