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Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization

Gastpar, R. ; Goldbrunner, M. ; Marko, D. ; Angerer, E. von



Abstract

The aim of this study was the identification of the essential structural elements in the 12-formyl-5,6-dihydroindolo[2, 1-a]isoquinoline system required for the inhibition of tubulin polymerization which is understood to be the predominant mode of action of this class of cytostatics. Since 2-phenylindole forms the main fragment of this tetracycle, it was used as the basic structure and modified ...

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