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Urine Metabolite Levels, Adverse Kidney Outcomes, and Mortality in CKD Patients: A Metabolome-wide Association Study

Steinbrenner, Inga ; Schultheiss, Ulla T. ; Kotsis, Fruzsina ; Schlosser, Pascal ; Stockmann, Helena ; Mohney, Robert P. ; Schmid, Matthias ; Oefner, Peter J. ; Eckardt, Kai-Uwe ; Köttgen, Anna ; Sekula, Peggy ; Eckardt, Kai-Uwe ; Meiselbach, Heike ; Schneider, Markus P. ; Schiffer, Mario ; Prokosch, Hans-Ulrich ; Bärthlein, Barbara ; Beck, Andreas ; Reis, André ; Ekici, Arif B. ; Becker, Susanne ; Becker-Grosspitsch, Dinah ; Alberth-Schmidt, Ulrike ; Hausknecht, Birgit ; Weigel, Anke ; Walz, Gerd ; Köttgen, Anna ; Schultheiß, Ulla T. ; Kotsis, Fruzsina ; Meder, Simone ; Mitsch, Erna ; Reinhard, Ursula ; Floege, Jürgen ; Saritas, Turgay ; Schaeffner, Elke ; Baid-Agrawal, Seema ; Theisen, Kerstin ; Haller, Hermann ; Menne, Jan ; Zeier, Martin ; Sommerer, Claudia ; Theilinger, Johanna ; Wolf, Gunter ; Busch, Martin ; Paul, Rainer ; Sitter, Thomas ; Wanner, Christoph ; Krane, Vera ; Börner-Klein, Antje ; Bauer, Britta ; Kronenberg, Florian ; Raschenberger, Julia ; Kollerits, Barbara ; Forer, Lukas ; Schönherr, Sebastian ; Weissensteiner, Hansi ; Oefner, Peter J. ; Gronwald, Wolfram ; Schmid, Matthias ; Nadal, Jennifer



Abstract

Rationale & Objective: Mechanisms underlying the variable course of disease progression in patients with chronic kidney disease (CKD) are incompletely understood. The aim of this study was to identify novel biomarkers of adverse kidney outcomes and overall mortality, which may offer insights into pathophysiologic mechanisms. Study Design: Metabolome-wide association study. Setting & Participants: ...

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